The article is devoted to the well-known dispute between R. Carnap and W.V.O. Quine on the meaning of statements with names of abstractions, which also revealed their disagreements on the more general question of the nature of the dependence of ontology on the choice of language of knowledge. According to Quine, the choice of language carries with it certain ontological commitments – judgments of existence that must be true for anyone who appropriately uses the language in question. The language of (...) abstractions (using appropriate names and indications) is widely used not only in philosophy and everyday communication, but also in the sciences, including natural sciences. The names of abstractions (or, alternatively, quantification by corresponding entities) cannot be completely excluded from science, as Carnap, in particular, points out. He also considers it wrong to attribute to a scientist with empiricist views the belief in the existence of something that he, as an empiricist, is not ready to consider existing. In his view, the choice of language (framework) does not carry any ontological obligations: it determines what should be the correct answer to the so-called internal questions of the theory but does not affect metaphysical questions. Carnap interprets meaningful statements about abstractions as analytical truths, while Quine believes that most references to abstractions are removable from the language of science, and those that are not removable create additional ontological obligations, which, however, for some reason say nothing about reality itself. But why this is so, if the theory implicating them claims to describe reality, is not clear. This debate about the role of judgments about abstractions in scientific knowledge gave rise to a whole branch of metaphysical and ontological research, best known as metaontology. The main parties in this dispute are realists, who interpret irreducible abstractions as part of reality and denotations of certain names, and anti-realists, who, as a rule, deny the connection of statements with such names with reality, treating them as pseudo-statements or something similar. The solution to the problem, which is proposed in this article, consists in abandoning the belief, widespread both in philosophy and in everyday thought, which can be generally called “The theory of reference” and which consists in the fact that the contribution of names and certain other types of expressions to communication is their denotations. If we assume that names have no denotations at all and their semantic contribution to statements is only their senses or something similar, then the names of abstractions in this respect will be no different from other types of names. In this case, it would be no need to either assume that they designate some “Platonic” entities in order for some statements with them being true, nor interpret these judgments as pseudo-statements or as truths of some special kind that are not related to reality. The interpretation of statements with such names and their evaluation will not pose any special problem for the empiricist with this approach. (shrink)

One of the major concerns of the social philosophy is the technological revolution and its impacts on the social systems. Critical views on the systems from the social philosophers depart from the social predicaments of their time. The pivotal critic of Karl Marx in his work of Das Capital, for example, is on poverty caused by the system of capitalism. Capitalism, for him, only produces various social downturns such as slavery, oppressions, exploitations and impoverishment. Herbert Marcuse, meanwhile, pointed at the (...) same problem, but he came from a different point of view from Marx. Marcuse criticized the abundant society. In One Dimensional Man Marcuse rendered a couple of incisive critics on the industrial society. Industrial society, for him, is marked by the abundance and surplus but this society is still oppressed under a new type of slavery, called voluntary slavery. We may briefly say that both philosophers rendered critics on the same matter of the industrial society, but the two stood on the different position. Marx’s critic was on the hungry and deficient society, while Marcuse on a satiated, plenteous and surplus society. The aim of this paper is to present of how Marcuse’s One-Dimensional Man ends in the digital age. (shrink)

There is a widely shared belief in contemporary epistemology that propositional knowledge is incompatible with certain kinds of luck, most of all with so called veritic luck. A subject is veritically lucky in his or her belief that p if this belief is true not due to its foundations (for example, reasons which an agent has to believe that p) but by mere accident. The acceptance of the thesis of incompatibility of knowledge with this kind of luck led to significant (...) modifications of a popular modern epistemological tripartite analysis of propositional knowledge according to which subject knows that p if and only if he or she believes that p is true, p is actually true, and an agent’s belief that p is true is justified. In his famous paper “Is True Justified Belief Knowledge” E. Gettier demonstrated that true justified belief may not be knowledge. The core of the problem is that in the cases described by Gettier and the like an agent’s belief, though justified, is true by accident. This gave rise to a set of theories introducing additional conditions of knowledge which could exclude veritic luck. In this paper the author critically discusses main modifications of the tripartite concept of knowledge aimed at making it independent on veritic luck, and show that they are unable to solve this problem. He agrees with those who think that the very thesis of incompatibility of knowledge with veritic luck is wrong. But he disagrees that all kinds of veritic luck are compatible with knowledge: the author supposes that good veritic luck is compatible with knowledge only when it compensates some negative effect of antecedent bad epistemic luck. According to this view original Gettier examples are not cases of knowledge whereas broken-clocks case and fake-barns case are. This account allows treating many classic cases of dependence of knowledge on luck as cases of knowledge-acquirement, but in the same time it excludes the inclusion into the class of knowledge such intuitively irrelevant outcomes as lucky guess and wishful thinking. (shrink)

The idea that knowledge as an individual mental attitude with certain propositional content is not only true justified belief but a belief the truth of which does not result from any kind of luck, is widely spread in contemporary epistemology. This account is known as anti-luck epistemology. A very popular explanation of the inconsistency of that concept of knowledge with the luck-dependent nature of truth (so called veritic luck taking place when a subject’s belief could not be true if not (...) by mere coincidence) presumes that the status of propositional knowledge crucially depends on the qualities of actions that result in the corresponding belief, or processes backing them, which reflect the socalled intellectual virtues mainly responsible for subject’s relevant competences. This account known as Virtue Epistemology presumes that if a belief is true exclusively or mainly due to its dependence on intellectual virtues, it just cannot be true by luck, hence no place for lucky knowledge. But this thesis is hard to prove given the existence of true virtuous beliefs which could nevertheless be false if not for some lucky (for the knower) accident. This led to an appearance of virtue epistemological theories aimed specifically at an assimilation of such cases. Their authors try to represent the relevant situations as such where the contribution of luck is not crucial whereas the contribution of virtues is crucial. This article provides a critical analysis of the corresponding arguments as part of a more general study of the ability of Virtue Epistemology to provide justification for the thesis of incompatibility of propositional knowledge with veritic luck. It is shown that there are good reasons to doubt that Virtue Epistemology can do this. (shrink)

The research sets out an organizing framework for the field of social ontology, the study of the of the nature of the social world. Social ontology is also gaining prominence in traditional philosophical discussions. The subject matter of social ontology is clarified, in particular the difference between it and the study of causal relations and the explanation of social phenomena. For any social fact, there are two distinct ontological questions: what is the ground for that fact, why is that fact (...) grounded just the way. Two different inquires are defined and explained: the study of how social categories are “anchored” or “grounded”. The distinction between these inquires is used to clarify prominent programs in social theory, particularly theories of practice and varieties of ontological individualism. Anchoring and grounding are two fundamental aspect to the building of the social world, Correspondingly, social ontology consists of two distinct project - “project of grounding” and “project of anchoring’. (shrink)

In Less Than Nothing, the pinnacle publication of a distinguished career, Slavoj i ek argues that it is imperative that we not simply return to Hegel but that we repeat and exceed his triumphs, overcoming his limitations by being even more ...

Book synopsis: In this combative major new work, philosophical sharpshooter Slavoj Zizek looks for the kernel of truth in the totalitarian politics of the past. Examining Heidegger's seduction by fascism and Foucault's flirtation with the Iranian Revolution, he suggests that these were the 'right steps in the wrong direction.' On the revolutionary terror of Robespierre, Mao and the bolsheviks, Zizek argues that while these struggles ended in historic failure and horror, there was a valuable core of idealism lost beneath the (...) bloodshed. A redemptive vision has been obscured by the soft, decentralized politics of the liberal-democratic consensus. Faced with the coming ecological crisis, Zizekk argues the case for revolutionary terror and the dictatorship of the proletariat. A return to past ideals is needed despite the risks. In the words of Samuel Beckett: 'Try again. Fail again. Fail better.'. (shrink)

This chapter provides a brief history of Kantianism in Russia since the late eighteenth century and identifies the main themes of Kantianism in Russia. It considers the reasons for the uneven and intermittent spread of Kantianism, the main motives behind the fierce resistance to Kantianism within the framework of certain trends of Orthodox thought, and the ways in which this philosophical polemic was reflected in the Russian literature. The achievements of Russian Kantianism are analyzed with attention to both its undeniable (...) merits and its weaknesses and inconsistencies. In addition, the scope and scale of Russian Kantianism will be compared with Schellingism and Hegelianism in Russia. On the basis of this comparison, I will argue against the stereotype that Russian philosophy is resistant to Kant. (shrink)

Critics attack normative ethical stakeholder theory for failing to recognize the special moral status of shareholders that justifiesthe fiduciary duties owed to them at law by managers. Stakeholder theorists reply that there is nothing morally significant about shareholders that can underwrite those fiduciary duties. I advance an argument that seeks to demonstrate both the special moral status of shareholders in a firm and the concomitant moral inadequacy of stakeholder theory. I argue that (i) if some relations morally requirefiduciary duties, and (...) (ii) the shareholder-manager relation possesses the features that make fiduciary duties morally necessary to thoserelations, then (iii) stakeholder theory is morally lacking. (shrink)

La Base de français médiéval (BFM) fait partie des corpus de français médiéval (9e-15e s.) les plus anciens et les plus utilisés par les linguistes diachroniciens et plus largement par tous ceux qui s’intéressent à l’histoire du français. Elle est le fruit d’une collaboration entre linguistes-philologues et spécialistes de la méthode textométrique implémentée dans la plateforme TXM. L’article présente un état des lieux du corpus BFM2022 focalisé sur la représentativité et l’interopérabilité des données. Il illustre l’apport des outils numériques pour (...) l’équilibrage des données et présente la stratégie de standardisation multi-niveau (structure textuelle, références, métadonnées, annotations) ayant permis à la Base de s’intégrer à des corpus diachroniques plus étendus pour des recherches en diachronie longue. (shrink)

To believe that every single scientist ought to be individually engaged in ethical thinking in order for science to be responsible at a collective level may be too demanding, if not plainly unrealistic. In fact, ethical labor is typically distributed across different kinds of scientists within the scientific community. Based on the empirical data collected within the Horizon 2020 ‘RRI-Practice’ project, we propose a classification of the members of the scientific community depending on their engagement in this collective activity. Our (...) classification offers, on the one hand, a model of how the ethical aspects of science are taken into consideration by scientists and, on the other, some indications on how to institutionalize ethics in science. (shrink)

Introduction. The problems of state and local governance in sparsely populated and rural areas is relevant for the Russian Federation due to the presence of depressed areas, depopulation of the countryside, small towns, monotowns, migration of the rural population to large cities, regional capitals, other regions and abroad. These processes are typical for many other modern states. Solving the problems of rural and sparsely populated areas includes providing socially significant services, protecting the health and safety of residents, developing education, creating (...) and maintaining social infrastructure, and creating jobs. The purpose of the article is to identify the most important management problems in rural and sparsely populated areas and reveal possible solutions to these problems using the example of Great Britain. Methods. The research is based on a systematic approach to management in rural and sparsely populated areas. Analysis of factual data, legal sources, published survey results, foreign Internet sources. Comparative analysis of problems and measures of state policy in different states. Scientific novelty of the research. The author highlights the current measures taken in the UK at the central, local levels in order to overcome the problems of rural and sparsely populated areas. These activities as a basis for developing practical recommendations may be important for solving similar problems in Russian regions, including in the context of the COVID-19 epidemic and economic problems in the near future. Results. As a result the author identifies problems in the field of management in rural and sparsely populated and hard-to-reach areas, as well as possible directions of state policy in the UK and Russia to overcome these problems. Conclusions. The most important direction of state policy for solving the problems highlighted in the study is the development of local interests of the community, the integration of state support measures and local events. As measures aimed at solving social and infrastructural problems of sparsely populated areas in the UK, one can single out government programs implemented at the national and regional levels with the participation of industrial enterprises and businesses, a grant mechanism for the implementation of financial support, combined with the empowerment of local communities. There is no such policy in Russia yet. (shrink)

The authors study opera from the perspective of the theories of psychoanalyst Jacques Lacan, and argue that opera's second death corresponded with the rise of psychoanalysis in the early 20th century. With a preface by Lanfossi and an afterword by Alberto Toscano.

We argue that the Rawlsian social contract argument advanced for stakeholder theory by R. Edward Freeman, writing alone and with William M. Evan, fails in three main ways. First, it is true to Rawls in neither form, nor purpose, nor the level of knowledge (or ignorance) required to motivate the veil of ignorance. Second, it fails to tailor the veil of ignorance to the fairness conditions that are required to solve the moral problem that Freeman and Evan set out to (...) solve (whereas Rawls’s own use of the device surely tailors the veil of ignorance to the problem of designing a just social order). Third, the argument, considered apart from its claimed Rawlsian pedigree, fails to bolster the stakeholder theory because it fails to demonstrate the rationality of adopting the institutional rules that Freeman and Evan favor. (shrink)

ABSTRACT This article contributes to methodological debates in contemporary critical theory regarding the scope and features of immanent critique. I spell out the philosophical commitments presupposed by this approach to criticism and identify its basic features by comparing it with more recognizable argumentative or interpretative strategies. This comparison yields three immanent-critical requirements – for inherence, contradiction, and access – which bring into relief the heuristic and ampliative character of immanent criticism. Yet, these requirements also imply that “immanent critique” is not (...) a method in any strict sense, since they are multiply interpretable and hence generative of distinctive critical comportments. (shrink)

The latest book by the Slovenian critic Slavoj Zizek takes the work of French philosopher Gilles Deleuze as the beginning of a dazzling inquiry into the realms of radical politics, philosophy, film (Hitchcock, Fight Club ), and psychoanalysis. Of Organs without Bodies Joan Copjec ( Imagine There's No Woman ) has written: "With all his ususal humor and invention, Zizek -- the acknowledged master of the 180 degree turn -- here takes a trip into "enemy" territory to deliver Deleuze of (...) a marvelously rebellious child, one that seriously challenges Deleuze's other progeny with a surprising but convincing bid for succession. Those who thought Deleuze's forward march into the future would follow a straight path are forced to rethink their stance. From now on all readings of Deleuze will have to take a detour through this important -- even necessary -- book." Eric Santner ( On the Psychopathology of Everyday Life ) describes Organs without Bodies as offering "an entirely new degree of conceptual clarity and political urgency. Through his deep engagement with the logic of Deleuze's project, Zizek opens up new possibilities of thought beyond the terms of the current political debates on globalization, democratization, war on terror. Once again, Zizek has produced an utterly timely and radically untimely meditation." Recently profiled in The New Yorker , and hailed by the Village Voice as "the giant of Ljubljana," Zizek is one of the most provocative and entertaining thinkers at work today. (shrink)

Life has semiotic nature; and as life forms differ in their complexity, functionality, and adaptability, we assume that forms of semiosis also vary accordingly. Here we propose a criterion to distinguish between the primitive kind of semiosis, which we call “protosemiosis” from the advanced kind of semiosis, or “eusemiosis”. In protosemiosis, agents associate signs directly with actions without considering objects, whereas in eusemiosis, agents associate signs with objects and only then possibly with actions. Protosemiosis started from the origin of life, (...) and eusemiosis started when evolving agents acquired the ability to track and classify objects. Eusemiosis is qualitatively different from protosemiosis because it can not be reduced to a small number of specific signaling pathways. Proto-signs can be classified into proto-icons that signal via single specific interaction, proto-indexes that combine several functions, and proto-symbols that are processed by a universal subagent equipped with a set of heritable adapters. Prefix “proto” is used here to characterize signs at the protosemiotic level. Although objects are not recognized by protosemiotic agents, they can be reliably reconstructed by human observers. In summary, protosemiosis is a primitive kind of semiosis that supports “know-how” without “know-what”. Without studying protosemiosis, the biosemiotics theory would be incomplete. (shrink)

Os autores convidados se dispuseram a escrever a fronteira tensa onde se vislumbra o que não pode ser escrito e demonstraram o 'inacabamento' do saber e a opacidade de um objeto que ou se recusa a ser apropriado por categorias filosóficas anteriores a Freud, ou exige a reinvenção de seus contornos. Por isso, também, o livro encontra-se dividido em seções criadas a partir das contribuições dos autores. Os organizadores recusaram, intencionalmente, o caminho fácil de aceitar as áreas de saber tradicionalmente (...) definidas no campo da filosofia, tais como epistemologia, ética, estética etc., como naturalmente dadas. Preferiram agrupar os trabalhos em temas que revelam de que modo aparecem alguns pontos críticos na interface entre as duas áreas - o tempo e a contingência, a coisa e o objeto, o conhecimento e o avesso. (shrink)

Although the term taxon is one of the most common concepts in biology, a range of its meanings cannot be comprehended by an universal definition. Usually, biologists construe their knowledge of “the same” taxon by substantially different interpretations, so they find themselves in need either to justify this “multiplication of taxon essences”, or to surmount their plurality unifying its interpretations into a single explanation of what a taxon is. In both cases, an ontological status (“reality”) of that taxon is questioned. (...) Therefore, discrepancy between universality of the taxon concept in biology and unavoidable plurality of its interpretations can be regarded as a source of problem of the taxon ontology. The present work aims to clarify the premises of this discrepancy using phenomenological approach. Three ways of the taxon positing (as a class, as a place in the world, and as a individualized body) have been distinguished. Taxon as a class is established by common essence that is shared by a set of living beings. These living beings are regarded as speculative objects beyond an idea of the world, i.e. as objects of the experimental science. A question about ontology of taxon as a class refers to the scholastic problem of universalia; its status can be defined within the scope of the nominalism/realism opposition. Taxon as a place of common appearance of the specimens is regarded in the context of the etiological relations unifying various entities into the entire world. Taxon as a place refers to a certain position in the Natural System that is construed as an etiological map of the world. In this case a specimen of a living being is known as a curiosity, i.e. representant of its relationships as well as of the place of its origin. Ontological status of a taxon as a place is to be clarified within the framework of the natural/artificial opposition. The positing of a taxon as a collective body marked off by limits of joint survival of living beings is characteristic for biology in the strict sense which arose in the very beginning of the 19 century. A taxon as a body established by the techniques of disciplinary power sensu M. Foucault extended from the human bodies to bodies of other living beings. The ontological status of a taxon as a collective body can be defined within the scope of the wild/domesticated opposition. Therefore, the discrepancy between the universality of the taxon concept and the plurality of its interpretations is underlayed by interpenetration of three distinct modi of taxon establishing. Distinguishing between these three modi can clarify sources of ontological problems concerned with the term taxon in each case when they arise. (shrink)

Recent work has shown that preschool-aged children and adults understand freedom of choice regardless of culture, but that adults across cultures differ in perceiving social obligations as constraints on action. To investigate the development of these cultural differences and universalities, we interviewed school-aged children (4–11) in Nepal and the United States regarding beliefs about people's freedom of choice and constraint to follow preferences, perform impossible acts, and break social obligations. Children across cultures and ages universally endorsed the choice to follow (...) preferences but not to perform impossible acts. Age and culture effects also emerged: Young children in both cultures viewed social obligations as constraints on action, but American children did so less as they aged. These findings suggest that while basic notions of free choice are universal, recognitions of social obligations as constraints on action may be culturally learned. (shrink)

This article summarizes the recommendations concerning robotics as issued by the Commission for the Ethics of Research in Information Sciences and Technologies (CERNA), the French advisory commission for the ethics of information and communication technology (ICT) research. Robotics has numerous applications in which its role can be overwhelming and may lead to unexpected consequences. In this rapidly evolving technological environment, CERNA does not set novel ethical standards but seeks to make ethical deliberation inseparable from scientific activity. Additionally, it provides tools (...) and guidance for researchers and research institutions. (shrink)

This essay offers a comparative analysis of the notion of trust in Hegel and Confucius. It shows that Hegel’s two senses of trust depend upon his theory of recognition and recognitive struggle. The competitive thrust of Hegel’s account of trust, it argues, introduces a series of problems that cannot be adequately resolved within his theory, since it presupposes the kinds of trusting relations—self-, intersubjective- and world-trust—that it purports to explain. This essay then turns to the Confucian notions of xin 心 (...) and li 理 to address the problems in the Hegelian account. It concludes by outlining the Confucian account’s salience for critical social theory. (shrink)

To explore the mechanism of sensation correlations between EP component amplitude and signal detection indices were studied. The time of sensation coincided with the peak latency of those EP components that showed a correlation with both indices. The components presumably reflected information synthesis in projection cortical neurons. A mechanism providing the synthesis process is proposed.

Numerous results about capturing complexity classes of queries by means of logical languages work for ordered structures only, and deal with non-generic, or order-dependent, queries. Recent attempts to improve the situation by characterizing wide classes of finite models where linear order is definable by certain simple means have not been very promising, as certain commonly believed conjectures were recently refuted (Dawar's Conjecture). We take on another approach that has to do with normalization of a given order (rather than with defining (...) a linear order from scratch). To this end, we show that normalizability of linear order is a strictly weaker condition than definability (say, in the least fixpoint logic), and still allows for extending Immerman-Vardi-style results to generic queries. It seems to be the weakest such condition. We then conjecture that linear order is normalizable in the least fixpoint logic for any finitely axiomatizable class of rigid structures. Truth of this conjecture, which is a strengthened version of Stolboushkin's conjecture, would have the same practical implications as Dawar's Conjecture. Finally, we suggest a series of reductions of the two conjectures to specialized classes of graphs, which we believe should simplify further work. (shrink)

We show that no formula of first order logic using linear ordering and the logical relation y = 2x can define the property that the size of a finite model is divisible by 3. This answers a long-standing question which may be of relevance to certain open problems in circuit complexity.

We show that no formula of first order logic using linear ordering and the logical relation $y = 2x$ can define the property that the size of a finite model is divisible by 3. This answers a long-standing question which may be of relevance to certain open problems in circuit complexity.

Recent work suggests a strong connection between intuitions regarding our own free will and our moral behavior. We investigate the origins of this link by asking whether preschool-aged children construe their own moral actions as freely chosen. We gave children the option to make three moral/social choices (avoiding harm to another, following a rule, and following peer behavior) and then asked them to retrospect as to whether they were free to have done otherwise. When given the choice to act (either (...) morally or immorally), children avoided harm and abided by rules, but they endorsed their freedom to have done otherwise. When choice was restricted by adult instruction, children did not endorse their free choice and indicated feeling constrained by moral obligation in their explanatory responses. These results suggest that children believe that their moral actions afford free will, but this belief is dependent on their experience of choice. (shrink)

This survey covers some of the main philosophical debates raised by the framework of effective field theories during the last decades. It is centered on three issues: whether effective field theories underpin a specific realist picture of the world, whether they support an anti-reductionist picture of physics, and whether they provide reasons to give up the ultimate aspiration of formulating a final and complete physical theory. Reviewing the past and current literature, we argue that effective field theories do not give (...) convincing reasons to adopt a particular stance towards these speculative issues. They hold good prospects for asking ontologically perspicuous and sensible questions about currently accessible domains. With respect to more fundamental questions, however, the only certainty is provisional and instrumental: effective theories are currently indispensable for conducting fruitful scientific research. (shrink)

Biological evolution is often viewed narrowly as a change of morphology or allele frequency in a sequence of generations. Here I pursue an alternative informational concept of evolution, as preservation, advance, and emergence of functional information in natural agents. Functional information is a network of signs that are used by agents to preserve and regulate their functions. Functional information is preserved in evolution via complex interplay of copying and construction processes: the digital components are copied, whereas interpreting subagents together with (...) scaffolds, tools, and resources, are constructed. Some of these processes are simple and invariant, whereas others are complex and contextual. Advance of functional information includes improvement and modification of already existing functions. Although the genome information may change passively and randomly, the interpretation is active and guided by the logic of agent behavior and embryonic development. Emergence of new functions is based on the reinterpretation of already existing information, when old tools, resources, and control algorithms are adopted for novel functions. Evolution of functional information progressed from protosemiosis, where signs correspond directly to actions, to eusemiosis, where agents associate signs with objects. Language is the most advanced form of eusemiosis, where the knowledge of objects and models is communicated between agents. (shrink)

Whenever the membranes of the egg in which the foetus emerges on its way to becoming a new-born are broken, imagine for a moment that something flies off, and that one can do it with an egg as easily as with a man, namely the hommelette, or the lamella. The lamella is something extra-flat, which moves like the amoeba. It is just a little more complicated. But it goes everywhere. And as it is something - I will tell you shortly (...) why - that is related to what the sexed being loses in sexuality, it is, like the amoeba in relation to sexed beings, immortal - because it survives any division, and scissiparous intervention. And it can turn around. Well! This is not very reassuring. But suppose it comes and envelopes your face while you are quietly asleep... I can't see how we would not join battle with a being capable of these properties. But it would not be a very convenient battle. This lamella, this organ, whose characteristic is not to exist, but which is nevertheless an organ - I can give you more details as to its zoological place - is the libido. It is the libido, qua pure life instinct, that is to say, immortal life, irrepressible life, life that has need of no organ, simplified, indestructible life. It is precisely what is subtracted from the living being by virtue of the fact that it is subject to the cycle of sexed reproduction. And it is of this that all the forms of the objet a that can be enumerated are the representatives, the equivalents. Every word has a weight here, in this deceivingly poetic description of the mythic creature called by Lacan "lamella". Lacan imagines lamella as a version of what Freud called "partial object": a weird organ which is magically autonomized, surviving without a body whose organ it should have been, like a hand that wonders around alone in early Surrealist films, or like the smile in Alice in Wonderland that persists alone, even when the Cheshire cat's body is no longer present: "'All right', said the Cat; and this time it vanished quite slowly, beginning with the end of the tail, and ending with the grin, which remained some time after the rest of it had gone. 'Well! I've often seen a cat without a grin', thought Alice; 'but a grin without a cat! It's the most curious thing I ever saw in my life!'" The lamella is an entity of pure surface, without the density of a substance, an infinitely plastic object that can not only incessantly change its form, but can even transpose itself from one to another medium: imagine a "something" that is first heard as a shrilling sound, and then pops up as a monstrously distorted body. A lamella is indivisible, indestructible, and immortal - more precisely, undead in the sense this term has in horror fiction: not the sublime spiritual immortality, but the obscene immortality of the "living dead" which, after every annihilation, re-composes themselves and clumsily goes on. As Lacan puts it in his terms, lamella does not exist, it insists: it is unreal, an entity of pure semblance, a multiplicity of appearances which seem to envelop a central void - its status is purely fantasmatic. This blind indestructible insistence of the libido is what Freud called "death drive," and one should bear in mind that "death drive" is, paradoxically, the Freudian name for its very opposite, for the way immortality appears within psychoanalysis: for an uncanny excess of life, for an "undead" urge which persist beyond the cycle of life and death, of generation and corruption. This is why Freud equates death drive with the so-called "compulsion-to-repeat," an uncanny urge to repeat painful past experiences which seems to outgrow the natural limitations of the organism affected by it and to insist even beyond the organism's death - again, like the living dead in a horror film who just go on. This excess inscribes itself into the human body in the guise of a wound which makes the subject "undead," depriving him of the capacity to die : when this wound is healed, the hero can die in peace. (shrink)

The purinergic signalling system, which utilises ATP, related nucleotides and adenosine as transmitter molecules, appeared very early in evolution: release mechanisms and ATP‐degrading enzymes are operative in bacteria, and the first specific receptors are present in single cell eukaryotic protozoa and algae. Further evolution of the purinergic signalling system resulted in the development of multiple classes of purinoceptors, several pathways for release of nucleotides and adenosine, and a system of ectonucleotidases controlling extracellular levels of purinergic transmitters. The purinergic signalling system (...) is expressed in virtually all types of tissues and cells, where it mediates numerous physiological reactions and contributes to pathological responses in a variety of diseases. (shrink)